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High prevalence of undiagnosed IBS in the US	08 June 2005

		This month's issue of Alimentary Pharmacology and Therapeutics finds that 77% of IBS sufferers in the US are undiagnosed, impacting on sufferers' well-being and health, and socioeconomic factors.

Hepatitis B virus infection in dialysis patients	07 June 2005

		The latest Alimentary Pharmacology & Therapeutics reports that anti-Hep B core antibody is related to anti-Hep C antibody supporting shared modes of transmission, and the rate of anti-Hep B virus core antibody is higher in seropositive dialysis patients.

Pathology predictors in upper endoscopy for dysphagia evaluation	07 June 2005

		Upper endoscopy is appropriate for initial evaluation of patients presenting with dysphagia, and should be considered in male patients over 40 years who report heartburn, odynophagia, or weight loss, finds the most recent Gastrointestinal Endoscopy.

Twin study shows little genetic influences in IBS	07 June 2005

		Genetic factors are of little or no influence on IBS where the predominant influences appear to be environmental, finds June's release of the American Journal of Gasroenterology.

Sedated versus unsedated esophagoscopy with video endoscope	06 June 2005

		Unsedated esophagoscopy with a 4-mm esophagoscope has diagnostic accuracy comparable to conventional endoscopy, and is tolerated best in patients with low anxiety levels and a high body mass index, reports June's issues of Endoscopy.

Primary care perceptions and management of GERD	06 June 2005

		Results of a national survey reported in the latest issue of the American Journal of Gastroenterology identifies a number of areas of controversy and confusion related to the management of GERD.

Quality of life after laparoscopic and open surgery for Crohn's	06 June 2005

		Quality of life is reduced in patients with Crohn's at long-term follow-up after both laparoscopic and open surgery, whilst recurrence is the only factor adversely affecting remission, finds the recent issue of Colorectal Diseases.

Clinical trial: treatment that improves colorectal cancer	03 June 2005

		Bevacizumab added to fluorouracil and leucovorin as first-line therapy for colorectal cancer, instead of irinotecan treatment, provides benefits including improvement in progression-free survival, reports June's Journal of Clinical Oncology.

PPI therapy reduces symptoms in non-cardiac chest pain	03 June 2005

		The latest study in the American Journal of Gastroenterology shows that PPI therapy reduces symptoms in non-cardiac chest pain and suggests it may be useful as a diagnostic test in identifying abnormal esophageal acid reflux.

Optimal combination treatments for esophagogastric cancer	03 June 2005

		The British Journal of Cancer this month confirms that capecitabine 625 mg m-2/bid is the optimal dose showing similar toxicity as 5-fluorouracil, whereas cisplatin replaced by oxaliplatin and 5-fluorouracil by capecitabine does not impair efficacy.

Type 2 diabetes is associated with pancreatic cancer	02 June 2005

		Research in the latest British Journal of Cancer shows a modest association between type 2 diabetes and pancreatic cancer.

Perioperative chemotherapy improves esophageal cancer survival	02 June 2005

		Patients with operable cancer of the stomach and lower esophagus who receive chemotherapy both before and after surgery live significantly longer than patients who receive surgery alone, reports the US National Cancer Institute.

Tobacco use after liver transplantation leads to nicotine addiction	01 June 2005

		Data in June's Liver Tranplantation highlight an underrecognized serious health risk for patients with liver transplantation for alcoholic liver disease and show a need for stringent tobacco use interventions pre- and post-liver transplantation.

Donor characteristics associated with liver graft survival	01 June 2005

		Research in this month's Transplantation shows a negative effect on graft survival with elderly donors, presenting with hypertension and metabolic acidosis, or a prolonged intensive care unit donor stay, whilst norepinephrine shows a protective effect.

Mucin causes gallstone development after bariatric surgery	01 June 2005

		Crystallization-promoting compounds play a role in the development of cholesterol crystals and gallstones in obese subjects during weight reduction, probably because of defective gallbladder emptying, reports June's issue of Hepatology.

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