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Coffee consumption reduces the risk of hepatocellular carcinoma	17 March 2005

		The odds ratios for hepatocellular carcinoma decreased for drinking more than 2 cups/day of coffee and drinking coffee was inversely associated with hepatocellular carcinoma regardless of its aetiology, finds the most recent issue of Journal of Hepatology

Predicting the response to infliximab in luminal Crohn's disease	17 March 2005

		Exclusive colonic involvement is the only predictive factor of sustained response to infliximab in luminal Crohn's disease and immunosuppressive therapy may favor sustained response, at least in women, reports the latest issue of Gastroenterologie Clinique et Biologique.

Prevalence, symptoms and treatment of constipation in infants	16 March 2005

		Milk of magnesia and polyethylene glycol were efficient and safe in the treatment of constipation in infants and toddlers, with a prevalence rate for constipation of 3% in the first year of life and 10% in the second, finds this month's issue of Journal of Pediatrics.

Diabetes increases the risk of hepatocellular carcinoma	16 March 2005

		The latest issue of Gut reports that diabetes is associated with a 2 to 3 fold increase in the risk of hepatocellular carcinoma, regardless of the presence of other major hepatocellular carcinoma risk factors.

Risk factors for osteoporosis in primary biliary cirrhosis	16 March 2005

		April's issue of Journal of Hepatology finds that osteoporosis is more prevalent in women with primary biliary cirrhosis than in the general population and the main risk factors are older age and severity of the disease, but not menopausal status.

Beneficial effect of low-carbohydrate diet in obese patients with diabetes	15 March 2005

		Weight loss, much improved 24-hour blood glucose profiles, insulin sensitivity, and hemoglobin A1c; and decreased plasma triglyceride and cholesterol levels was completely accounted for by reduced caloric intake, finds today's issue of Annals of Internal Medicine.

Capsule endoscopy useful in assessing patients with celiac disease	15 March 2005

		Familiarity with capsule endoscopy technology appears to be a critical factor affecting the accuracy of assessing patients with celiac disease, finds March's issue of the American Journal of Gastroenterology.

Meta-analysis: Proton pump inhibitor therapy in peptic ulcer bleeding	15 March 2005

		Treatment with a proton pump inhibitor reduces the risk of rebleeding and the requirement for surgery after ulcer bleeding but has no benefit on overall mortality, reports this weeks British Medical Journal.

Prevalence of occult Hep B in a community-based population	14 March 2005

		Occult Hep B is higher in those with serologic evidence of previous Hep B virus infection than Hep B seronegative individuals and age, gender and liver biochemistry findings do not identify those with occult Hep B, finds the most recent issue of Journal of Hepatology.

Desipramine can predict a clinical response in bowel disorders	14 March 2005

		Blood levels of Desipramine are associated with a clinical response in functional bowel disorders, however, with dosages up to 150 mg, there is no relationship between total dose or plasma level and the clinical response, reports the latest issue of American Journal of Gastroenterology

Cigarette smoking accelerates progression of alcoholic pancreatitis	14 March 2005

		April's issue of Gut reports that tobacco smoking increases significantly the risk of pancreatic calcifications for smokers versus non-smokers and to a lesser extent the risk of diabetes during the course of pancreatitis.

Predictive model for identifying Hep B without significant liver fibrosis	11 March 2005

		Application of this non-invasive model could provide useful information on the stage of disease, guide future management decisions, and potentially decrease the need for liver biopsy in some patients with chronic Hep B, finds this month's American Journal of Gastroenterology.

Clinical trial: Laparoscopic versus open appendicectomy for appendicitis	11 March 2005

		Functional status was significantly better in the laparoscopic appendicectomy group 7-10 days after operation and a trend towards better physical activity was noted after the laparoscopic procedure, reports March's issue of the British Journal of Surgery.

Ribavirin may reduce use of clotting factors in hemophilia and Hep C	11 March 2005

		Findings based on case series in this week's issue of JAMA, show that ribavirin in combination with interferon, and possibly alone, may reduce the use of clotting factors in patients with hemophilia and chronic Hepatitis C.

H pylori infection may protect against esophageal carcinoma	10 March 2005

		This month's The American Journal of Gastroenterology finds that subjects with positive H pylori infections had a significantly reduced risk of developing esophageal squamous-cell carcinoma than those without.

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