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Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD). It may also have an impact on the histologic severity of NAFLD. However, data on this association are limited. Dr Veeravicha Jaruvongvanich and colleagues conducted this meta-analysis to investigate the relationship of serum uric acid with liver histologic severity as determined by NAFLD activity score in patients with NAFLD.  | | The pooled odds ratio for a high NAFLD activity score in patients with hyperuricemia was 2.2 | | European Journal of Gastroenterology & Hepatology |
MEDLINE and EMBASE databases were searched through 2016 for studies that investigated the association between hyperuricemia and NAFLD activity score among patients with biopsy-proven NAFLD. Pooled odds ratio and 95% confidence interval were calculated using a random-effects model. The team identified 5 observational studies with 777 NAFLD patients. Patients with NAFLD who had hyperuricemia had a high NAFLD activity score significantly more often than did those without hyperuricemia with a pooled odds ratio of 2.2. Dr Jaruvongvanich's team comments, "In patients with NAFLD, hyperuricemia is associated with a higher degree of histological liver damage." "Further studies are required to establish the role of uric acid-lowering therapy among these patients."
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