|The resulting increase in intestinal permeability leads to low-grade inflammation|
|American Journal of Gastroenterology|
The resulting increase in intestinal permeability leads to low-grade inflammation.
The research team found nonsteroidal anti-inflammatory drug inhibition of cyclooxygenase enzymes, along with luminal aggressors, results in erosions and ulcers, with potential complications of bleeding, protein loss, stricture formation, and perforation.
Dr Bjarnason's team concludes, "We propose a model for nonsteroidal anti-inflammatory drug-induced damage to the gastrointestinal tract that includes these complex, interacting, and inter-dependent factors."
"This model highlights the obstacles for the development of safer nonsteroidal anti-inflammatory drugs."