Proton pump inhibitors (PPI) are among the top 10 most prescribed medications worldwide.
Dr Andrew Chan and colleagues Massachusetts, USA investigated the association between PPI use and ischemic stroke.
The team collected data on 68,514 women enrolled in the Nurses’ Health Study since 2000 and 28,989 men in the Health Professionals Follow-up Study since 2004, without a history of stroke.
The team's primary end point was first incident stroke.
|Regular PPI use was not associated with increased risk of stroke overall|
In the 2 cohorts, the researchers documented 2599 incident strokes over a 12-year period, encompassing 949,330 person-years.
After adjustment for established risk factors for stroke, PPI use was associated with a significant increase in risk of ischemic stroke.
The research team found that the association was reduced after we adjusted for potential indications for PPI use, including history of peptic ulcer disease, gastroesophageal reflux disease, or gastrointestinal bleeding, and prior use of histamine-2 receptor antagonist therapy.
Regular PPI use was not associated with increased risk of stroke overall or hemorrhagic stroke.
Dr Chan's team comments, "In an analysis of data from the Nurses’ Health Study and the Health Professionals Follow-up Study, we did not find a significant association between PPI use and ischemic stroke, after accounting for indications for PPI use."
"Prior reports of an increased risk of stroke may be due to residual confounding related to chronic conditions associated with PPI use."