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fiogf49gjkf04 Dr Stefano Fagiuoli and colleagues from Italy performed a retrospective data analysis on liver transplantation for Wilson's disease from Liver Transplant Centers.
The investigators identified 37 cases included in the analysis.
The main indication for liver transplantation was chronic advanced liver disease in 78% of patients.
The investigative team recorded mixed hepatic and neuropsychiatric symptoms in 32%.
The team noted that 8 patients presented with fulminant liver failure, and 45% were on medical treatment.
Patient survival at 3 months, 12 months, 3 years, 5 years, and 10 years after transplantation were, respectively, 92%, 89%, 83%, 76%, and 59%.  | | Neurological symptoms significantly improved after orthotopic liver transplantation | | Liver Transplantation |
The investigators found that graft survival at 3 months, 12 months, 3 years, 5 years, and 10 years and 85%, 83%, 77%, 70%, and 47%.
The investigators observed that neurological symptoms significantly improved after orthotopic liver transplantation.
The survival of patients with mixed hepatic and neuropsychiatric involvement was significantly lower than in patients with liver disease alone.
The team noted that Wilson's disease characterized by hepatic involvement alone was a good indication for a liver transplant when specific medical therapy fails.
Patients with neuropsychiatric signs had a significantly shorter survival even though liver transplantation has a positive impact on neurological symptoms.
Dr Fagiuoli's team commented, “A combination of hepatic and neuropsychiatric conditions deserves careful neurological evaluation, which should contraindicate orthotopic liver transplantation in case of severe neurological impairment.”
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