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 10 August 2022

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News

H pylori re-infection after successful eradication is low

Re-infection after successful H pylori eradication is probably less common than previously thought, with a re-infection rate of less than 1% per year, reports the latest Alimentary Pharmacology of Therapeutics.

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Re-infection with Helicobacter pylori after eradication has been estimated to occur in none to14% of patients.

Most so-called 're-infections' occur within the first year following 'eradication' and many may actually be due to recrudescence of a temporarily suppressed infection.

Dr Cameron and colleagues from England studied the true re-infection rate after eradication therapy.

The research team excluded the first year's data, thereby minimizing the possible confounding effect of recrudescence.

The team evaluated 1162 patients for H pylori infection following eradication therapy between 1987 and 2004.

Re-infection occurred in 13 out of 1162 cases
Alimentary Pharmacology & Therapeutics

Testing was carried out by urea breath test and gastric biopsy.

Patients were included if they were found to be negative for H pylori infection by testing at least 1 year following eradication.

The patients also underwent at least 1 further test for H pylori.

The median post-eradication follow-up was 3 years, and included 4668 tests.

The research team analyzed 3319 years of follow-up.

The team found that 13 cases of re-infection occurred, a re-infection rate of less than 1% per year.

Dr Cameron's team commented, “This large study of H pylori re-infection avoided cases of recrudescence by excluding the first post-eradication year.”

“True re-infection is probably less common than previously thought.”

Aliment Pharmacol Ther 2006: 23(9)1355
21 April 2006

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